Seki-juku, with “seki” meaning checkpoint, was a post town with a checkpoint as the name suggests. However, it was not a checkpoint in Edo period, but was built in 672 at the time of Jinshin War. It was known as Suzuka no Seki at that time and was referred to as one of Three Great Checkpoints in ancient Japan, along with Arachi in Echizen and Fuwa in Minou. The checkpoints were abolished in 789.
During the Middle Ages, under the control of Seki Clan, the town developed around Jizou-in Temple first as a temple town and later prospered as a post town.
In 1601 (Edo period), Tokugawa government brought back the checkpoint system and Seki-juku became the 47th post town starting from Shinagawa-juku, covering the present areas of  Kizaki, Nakamachi and Shinjo in Seki Town, Kameyama, Mie Prefecture. The area is the only post town along Fifty-three Sations of the Toukaidou where stores and houses from ancient times still remain intact. Since it was designated as an Important Cultural Buildings Preservation District in 1984, the town has been reinventing itself utilizing and preserving unique local historical assets.
Seki-juku post town consist of four boroughs each with unique characteristics; Kizaki, where a line of low rise housing exists: Nakamachi with “honjin” (inns for lords and samurai) , “hatago” (inns for general people) and wholesalers gathered: Shinjo, an area in front of Jizou-in Temple: Kitaura where there are many temples and shrines.

Sekijuku, located in Seki-cho, Kameyama-shi, Mie Prefecture, is the only place where the past has left a trace of the memories of the Tokaido, the old coastal road between Edo and Kyoto.

Seki-cho lies at the eastern foot of Mt Suzuka. Isesuzuka-no-seki was originally a checkpoint in Seki-cho, that, along with Echizen-no-arachi and Mino-no-Fuwa, was one of three major checkpoints along the Tokaido. (A 'seki' or 'sekisho' was a barrier station on thoroughfares between provinces, where the movement of criminals, weapons, hostages, etc. could be checked.)

The current structure of the town was probably created by Seki Morinobu, who also constructed neighboring roads and the town of Nakamachi, which lies between Shinsho and Kizaki. As time passed, the streets of Nakamachi and the town itself grew and developed eastwards, eventually becoming the larger town it is today. By the late Edo period, Sekijuku had become the main post station on the Tokaido Shukuba.

In 1984, Sekijuku was designated as an Important Historic Preservation District. The Seki-Jizoin, which was nominated as an Important National Cultural Property can also be found in this district. The streets of Sekijuku are a precious reminder of the history of the Tokaido.